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Deep Soren, Amar
- Genotoxicity of Beta-Sitosterol, Betulinic Acid, Biochanin A, and Ursolic Acid, Potential Anthelmintic Phyto-Compounds
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Authors
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1 Department of Zoology, North-Eastern Hill University, Shillong – 793022, Meghalaya, IN
2 PG and Research Department of Zoology, B. Borooah College, Guwahati – 781007, Assam, IN
1 Department of Zoology, North-Eastern Hill University, Shillong – 793022, Meghalaya, IN
2 PG and Research Department of Zoology, B. Borooah College, Guwahati – 781007, Assam, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 30, No 2 (2023), Pagination: 155-160Abstract
Beta-sitosterol, betulinic acid, biochanin A and ursolic acid are known to possess anthelmintic properties. This study was undertaken to assess the genotoxic potentials of these phytocompounds in albino rats. Animals were orally administered with 1 and 10 mg/ml of the above phyto-compounds for a period of 14 days. All the animals were subjected to mitotic arrest before sacrifice and then bone marrow cells were collected from both the femurs and processed to observe the chromosomal aberrations. The results revealed that ursolic acid induced the maximum number of statistically significant abnormalities (p ≤ 0.05) followed by betulinic acid and biochanin A. Beta-sitosterol was found to be the safest of all the tested phytocompounds as far as chromosomal abnormalities in short term oral studies are concerned as it did not lead to major changes at genomic level. Although these phyto-compounds are considered potential anthelmintics, their long-term use may cause genotoxic effects to the users.Keywords
beta sitosterol, betulinic acid, biochanin A, genotoxicity, ursolic acid.
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- Genotoxicity Assessment and Toxic Metal Contamination of Traditionally used Anthelmintic Medicinal Plants in Assam, India
Abstract Views :141 |
PDF Views:0
Authors
Affiliations
1 PG and Research Department of Zoology, B. Borooah College, Guwahati, 781007, Assam, IN
2 Department of Zoology, North-Eastern Hill University, Shillong, 793022, Meghalaya, IN
1 PG and Research Department of Zoology, B. Borooah College, Guwahati, 781007, Assam, IN
2 Department of Zoology, North-Eastern Hill University, Shillong, 793022, Meghalaya, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 30, No 2 (2023), Pagination: 249-254Abstract
Medicinal plants possess several metals obtained naturally or through pollution. The study evaluates the genotoxic potentials and the presence of essential elements and toxic metals in Sesbania sesban var. bicolor (leaves), Cyperus compressus (roots), and Asparagus racemosus (roots), which are used as anthelmintics in the traditional medicine of the Santhals in India. A genotoxicity study was performed in rats as per Organization for Economic Co-operation and Development guidelines. Element contents were evaluated using inductively coupled plasma-optical emission spectrometry. Administration of S. sesban var. bicolor (400 mg/kg), C. compressus (700 mg/kg) and A. racemosus (500 mg/kg) did not cause any abnormalities in the chromosomes. Elemental analysis revealed the presence of lead (5.00±0.05, 4.98±0.01, 4.99±0.07 ppm), cadmium (4.99±0.04, 4.90±0.03, 5.00±0.08 ppm) and arsenic (0.98±0.03, 0.41±0.05, 0.92±0.03 ppm), respectively. Although their genotoxic potential was lacking, the presence of toxic metals in them is a cause for concern.Keywords
Asparagus racemosus, Cyperus compressus, Genotoxicity, Sesbania sesban var. bicolor, Toxic Metals.References
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